Post-treatment imaging and dosimetry significantly improve patient management and safety in radiopharmaceutical therapy, according to case studies presented at the 2025 SNMMI Annual Meeting. The case studies, published in The Journal of Nuclear Medicine, show that post-therapy imaging helps clinicians make more informed decisions, personalize treatments and identify complications, researcher Taylor Gillespie of the University of Tennessee Medical Center said.

A novel monoclonal antibody-based PET tracer, 89Zr-Zr-DFO-F8, can better distinguish subtypes of triple-negative breast cancer by targeting disease-specific extracellular matrix protein domain A of fibronectin, a protein highly expressed in breast cancer. Researchers noted in The Journal of Nuclear Medicine that in vitro and in vivo tests showed the agent's high tumor uptake and that it outperforms the standard of care 18F-FDG tracer.

A Phase 1 trial has shown that 225Ac-LNC1011 targeted alpha therapy has an objective response rate of 50% in patients with PSMA-positive prostate cancer, according to RECIST v1.1 criteria, and a 75% objective response rate, according to PERCIST v1.0 guidelines. The therapy also led to significant reductions in PSA levels and had an acceptable toxicity profile, researchers reported at the 2025 SNMMI Annual Meeting.

Radiopharm Theranostics has partnered with Cyclotek to supply terbium-161 for a Phase 1 clinical trial of RAD 402, a radiotherapeutic targeting prostate cancer. The trial is expected to begin in the second half of this year; a completed preclinical data package demonstrated safety and promising biodistribution.

Telix Pharmaceuticals' facility in Brussels has delivered its first good manufacturing practice-grade commercial radiopharmaceutical doses to a hospital collaboration in Charleroi, Belgium. The company's Telix Manufacturing Solutions in Brussels South has nine GMP lines, a radiopharmacy, clean rooms and two cyclotrons.

The Supreme Court has rejected a challenge to the Affordable Care Act, ensuring continued access to free preventive services such as cancer screenings and HIV drugs for 150 million Americans. The 6-3 decision affirms that the HHS secretary has the authority to remove members of the task force that recommends these services.

Senate Republican leaders have increased the rural hospital relief fund from $15 billion to $25 billion to be distributed over five years as part of discussions on the federal budget bill. This increase is significantly less than the $100 billion requested by Sen. Susan Collins to support rural hospitals, nursing homes and community health centers.

Common typographical errors, extra spaces, slang, uncertain language and missing gender references can reduce the accuracy of AI programs that analyze health records, according to a presentation at an Association for Computing Machinery meeting. These elements increased the likelihood that AI would recommend self-management of health problems instead of an appointment with a health care professional, particularly for female patients.

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) welcomed 7,800 physicians, technologists, pharmacists, laboratory professionals, scientists, industry leaders and patients this week at its 2025 Annual Meeting in New Orleans, themed "Accelerating the Cure." Catch up on the happenings here.

This year's meeting was jam-packed with scientific sessions, awards ceremonies, and networking events. Before we look to the year ahead, let's take one more look at the highlights from the New Orleans meeting. Watch here.