SNMMI SmartBrief
Bacterial signal peptides may be useful in radiopharmaceuticals
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September 16, 2025
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Top Story
 
PET/MRI may improve staging for patients with rectal cancer
A study in the International Journal of Colorectal Disease found F-18 FDG PET/MRI may be better than standard imaging for preoperative staging of rectal cancer. The research found PET/MRI changed the clinical stage in 64% of cases and altered clinical management in 26% of cases.
Full Story: AuntMinnie (free registration) (9/16)
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The future of radiopharmaceuticals is here. Jubilant Radiopharmacies' new paper breaks down the top 5 trends in radiopharmaceuticals reshaping the nuclear medicine industry, including theranostics, reimbursement shifts, supply chain and more.
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Clinical News & Research
 
Study finds 7% cancer rate in patients with incidental prostate lesions
A study presented at the South Central American Urological Association's annual meeting found that 2.5% of patients undergoing FDG PET/CT scans for reasons other than prostate cancer had incidental prostate lesions, and 7% of those patients were ultimately diagnosed with prostate cancer. The study covered scans conducted from January 2019 to July 2024.
Full Story: UroToday (9/14)
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International panel standardizes PSMA PET/CT reporting
The Standardised PSMA PET/CT Analysis and Reporting Consensus project has established a unified framework for reporting PSMA PET/CT scans, which are increasingly used to diagnose prostate cancer. "Integration of common PSMA PET reporting criteria under one umbrella improves the explanation of imaging findings between imaging experts and treating clinicians for clinical implementation," researchers wrote in the journal European Urology.
Full Story: ScienceDirect (9/13)
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Bacterial signal peptides may be useful in radiopharmaceuticals
A study published in Scientific Reports found that radiolabeled bacterial signal peptides could be useful in developing radiopharmaceuticals targeting formyl peptide receptors, which are highly expressed on tumor cells. Researchers developed a FPR1-selective radiotracer using the bacterial signal peptide f-MVPIKI, which showed rapid binding and stability in preclinical studies.
Full Story: Scientific Reports (9/12)
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Physician: Team work is basis of successful cardiac imaging
Multimodality imaging is becoming essential in cardiac care, requiring specialists trained in nuclear medicine, echocardiography, cardiac MRI and CT, according to Dr. Wael Jaber, director of nuclear cardiology and professor of medicine at Cleveland Clinic. "Patients don't ask to see a nuclear cardiologist or a heart failure doctor," Jaber said. "They come with a problem, and it's the team that solves it. The team is here to stay--and I can't see us going back to fragmentation."
Full Story: Cardiovascular Business (9/15)
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Best practices for sourcing radioisotopes
Featuring best practices and regulatory insights, our new white paper breaks down the hidden cracks in the radiopharmaceutical supply chain, how to optimize procurement strategies, and why supplier partnerships are key to continuity of care.
Read more.
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News from the Field
 
Email security breaches common in health care
A Paubox survey found 52% of health care sector email breaches in 2024 involved Microsoft 365, up from 43% in 2023. Ineffective DMARC protection was seen in 79% of breached organizations, compared with 65% in 2024, and 16% of breaches involved business associates. More than 40% of respondents said that secure messaging had been bypassed at least once over the past year. "What we're seeing is a perfect storm of limited resources, expanding attack surfaces and security strategies that rely too heavily on human vigilance," said Paubox Chief Compliance Officer Rick Kuwahara.
Full Story: IT Pro (9/15)
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Medical professional liability rates keep climbing
The medical professional liability insurance market remains challenging, with rates rising by double digits in the first half of the year, according to Marsh. Among hospitals, 45% of clients have experienced increases of 10% to 25%, while 10% have seen hikes of 25% to 50%.
Full Story: Business Insurance (9/12)
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Scratch Taste, Zero Hassle
Idahoan potatoes bring the flavor guests crave with the speed kitchens need. Easy to prep, consistent every time, and full of comfort — it's scratch quality made simple.
See the difference with a free sample today.
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International Developments
 
Canadian university gets $18M to boost isotope production
The Ontario government is investing $18 million to expand isotope production at McMaster University's nuclear reactor in Hamilton. The funding will allow the reactor to operate around the clock, potentially increasing annual treatments from 70,000 to 84,000.
Full Story: CHCH-TV (Ontario) (9/15)
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Building a Scalable Customer 360 in Healthcare
On October 2 at 1 PM EST, discover how to link data across platforms and tackle governance challenges. Learn from Baylor Scott & White's digital and analytics leaders in this webinar to find out how they replaced IBM initiate and built a phased Customer 360 to unify 46M identities across Epic, Snowflake, and JV Systems.
Register Now!
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Health Policy
 
Families face tough decisions if ACA subsidies expire
The slated expiration of Affordable Care Act subsidies at the end of the year may have a big effect on millions of families facing significant increases in premiums. Some may shift to high-deductible plans that offer lower premiums but higher out-of-pocket costs and others may have to choose between maintaining their health coverage and cutting essential household expenses. There is support among Democrats and some Republicans for extending the subsidies but it's not clear whether it will be included in upcoming legislation.
Full Story: The Associated Press (9/13), NBC News (9/13)
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