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Plus: The push to bring cash pricing to employers Read in browser
Endpoints News
Thursday, 30 October 2025
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Goodbye, Middleman. Hello, Littleman.
With the rising success of cash-pay options for GLP-1 drugs from Eli Lilly and Novo Nordisk, more healthcare companies have been talking to me about how to grow the self-pay market for weight loss drugs.
It's a concept that lets an employer offer a benefit to cover some of the cash price for weight loss medication, but without actually having the drugs on the company's coverage formulary through its PBM. For instance, an employer could cover $200 of the monthly cash price, with the employee on the hook for the rest. 
When we first started hearing of these direct-to-employer initiatives, my editor Drew asked me the very fair question: Is this just a lighter-touch middleman? Let's call this plan design... the littleman. 
The littleman approach offers some advantages for a unique drug category. Many Americans get health benefits through their employer, and they want to use them. But when it comes to obesity care, only about 20% of employers with more than 200 employees in 2025 offer coverage for GLP-1s used for weight loss.
"I think the direct-to-patient model fills a lot of current gaps, but I think the direct-to-employer model is actually a more sustainable model," Bethanie Stein, president of Humana’s pharmacy business, including CenterWell pharmacy, told me. CenterWell is a dispensing partner to Novo Nordisk’s NovoCare Pharmacy, which offers self-pay pricing for the company’s GLP-1s. Direct-to-employer programs, Stein said, is something the company is "currently exploring."
It’s an area manufacturers are exploring, too. 
"For us, it's just important to understand how we play a role there," Dave Moore, executive vice president of US operations at Novo Nordisk told me.
And Jennifer Mazur, LillyDirect general manager, said that there’s an opportunity to look at the employer market differently. 
"We're trying to expand access for patients, and doing that within the existing constraints of our current delivery is not proving to be effective," Mazur said.
If my conversations at HLTH last week are any indication, I’d expect you’ll be reading a lot more of these "littleman" type of arrangements in this newsletter over the next few months.
- Lydia
P.S. - We’re officially one week away from our Health Tech Day! During the virtual daytime portion, we’ll be chatting about the impact of the Trump administration on health tech, what’s ahead as the IPO market had a slight thaw this year and AI’s evolving role in how healthcare is paid for and delivered. Then, (if you’re in NYC) I hope you’ll join me for an in-person happy hour, including a conversation with Maven Clinic CEO Kate Ryder. Get your tickets here.
Here’s what’s new
Novo Nordisk's direct-to-patient platform gains momentum as self-pay sales rise
Con­sumers are hav­ing an en­tire­ly dif­fer­ent re­la­tion­ship with how they ac­cess weight loss drugs, buy­ing them even if there isn’t in­sur­ance cov­er­age. And it's push­ing drug­mak­ers to act dif­fer­ent­ly.

“It’s not a normal thing for us on the manufacturer side,” Dave Moore, executive vice president of US operations at Novo Nordisk, told Endpoints News.
More than a third of Lilly's new Zepbound prescriptions are coming from DTC program
The im­pact of phar­ma’s di­rect-to-pa­tient ef­forts is gaining clarity. As of the second quarter of 2025, LillyDirect — including sales that come from cash-paying patients — makes up 35% of new prescriptions of Zepbound, LillyDirect general manager Jennifer Mazur told Endpoints.
Scribing startups are reinventing themselves beyond notetaking as shakeout nears
AI scribes have been one of the hottest ar­eas in health­care, rais­ing $1.6 bil­lion so far this year alone. But as health IT gi­ants like Epic roll out their own ver­sions, clin­i­cal scrib­ing star­tups are rac­ing to do more.
Lilly keeps up legal fight against GLP-1 compounders 
De­spite re­cent set­backs in court, Eli Lil­ly is dou­bling down on its fight against com­pound­ed weight loss drugs.
Quote of the week
“It’s getting very blurry where scribing ends and these beyond the notes features begin. So the future is to drop a bomb on scribing and just develop this whole assistive suite of beyond the note features.”
Ian Shakil, chief strategy officer at Commure
This week in health Тech
CVS Health took a $5.7 billion impairment charge related to its healthcare delivery business. Despite the segment’s performance being in line with expectations, “our decision during the quarter to temper Oak Street Health clinic growth over the next few years was the primary reason for reporting this charge,” CEO David Joyner said on Wednesday’s earnings call, according to an AlphaSense transcript.
Centene also took an impairment charge. Centene attributed the $6.7 billion impairment to the drop in its stock price after it withdrew its 2025 outlook in July. The ACA marketplace in particular has weighed on the insurer’s valuation this year.
Teladoc's third-quarter revenue is down 2% compared to last year, the company said Wednesday. CEO Chuck Divita characterized 2025 as a year of repositioning as the telehealth company tries to turn its mental health business toward insurance and use more AI tools for chronic care.
UnitedHealth Group, still in recovery mode, beat on its third-quarter earnings Tuesday. The company grew its third-quarter revenue to $113.2 billion, up from $100.8 billion in the same quarter in 2024.

Lilly inked its first LillyDirect retail partnership with Walmart. (ICYMI, I wrote more about Lilly’s DTC strategy for today’s newsletter!) 

Nvidia announced a slew of health tech partnerships at its Global Technology Conference on Tuesday: Alphabet's life sciences arm Verily is using Nvidia's AI to speed up research. Innovaccer is using Nvidia's AI to speed up its AI built for administrative tasks. Johnson & Johnson MedTech is using Nvidia's AI to help build robots for surgery. And Lilly and Nvidia have agreed to build what they say will be pharma's largest supercomputer to discover and design medicines. While many companies have already been using Nvidia's hardware, more are starting to use its software as well.
Indomo, a startup aiming to make acne injections available at home, raised $25 million. Atomic, Foresite Capital and Polaris Partners invested in the company.
Arya Health raised $18.2 million for AI agents to tackle administrative tasks in home health and ongoing care outside the hospital. ACME Capital led the Series A.
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