SNMMI SmartBrief
18F-FDG PET/CT may predict depression in young cancer survivors
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October 31, 2025
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FDG-PET/CT may help diagnose metastatic uveal melanoma
A retrospective study published in the journal Cancer Imaging found that F-18 FDG-PET/CT may help diagnose metastatic uveal melanoma. "[PET/CT] is a very sensitive and specific tool for the early detection and localization of metastatic disease in patients with UM, particularly in bone and lymph node," researchers said.
Full Story: AuntMinnie (free registration) (10/30)
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Evolving practices in lymphatic mapping
Join our panel of experts for a discussion on evolving trends in surgical de-escalation and the role of sentinel lymph node biopsy. Panelists will present case studies including the use of a receptor-targeted radiotracer, designed to precisely identify sentinel lymph nodes for solid tumors.
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Clinical News & Research
 
Study supports feasibility of LuPSMA-I plus Ra in mCRPC
A study published in The Lancet Oncology found that combining LuPSMA-I and bone-seeking α-emitter radium-223 is safe and feasible for patients with metastatic castration-resistant prostate cancer. The study found that the combination demonstrated antitumor activity, with a 55% reduction in PSA levels in half of patients.
Full Story: Cancer Network (10/30)
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18F-FDG PET/CT may predict depression in young cancer survivors
A study published in Translational Psychiatry found that 18F-FDG PET/CT imaging can predict depression in adolescent and early young adult cancer survivors. The study tracked patients ages 15 to 25 in remission and suggested a factor may be metabolic changes in several brain regions as seen on 18-F FDG PET/CT imaging.
Full Story: Nature (10/31)
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AI is the Future of Commerce. Stay Ahead.
AI isn't hype anymore—it's here. Join EPAM, Stripe, and commercetools to learn how to harness AI—responsibly and effectively. See how AI is reshaping the shopper journey, and learn why composability is key to doing it right. The brands moving first are already winning. Register now!
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Industry Report
 
Sirona Medical receives FDA clearance for imaging suite
Sirona Medical has received 510(k) clearance from the FDA for its Sirona Advanced Imaging Suite. The suite, a class II device, enhances diagnostic imaging with features such as PET/CT support and quantitative standard uptake value analysis.
Full Story: AuntMinnie (free registration) (10/30)
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The JNM Podcast, but Spooky
What's in the blood? That's the question our panel of experts are asking about biomarkers in prostate cancer in the latest episode of the JNM podcast. In case you missed it, here's your reminder to tune in to hear more about how "liquid biopsy" can help us gain vital insights about a disease and its progression. Listen now!
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News from the Field
 
Long-term study shows benefits, harms of PSA screening
PSA screening results in a 13% reduction in prostate cancer mortality over 23 years, according to a study published in The New England Journal of Medicine. The number needed to screen and diagnose to prevent one death decreased, indicating a more favorable harm-to-benefit ratio than previously thought. However, the study also raises concerns about overdiagnosis and unnecessary interventions, with 27 extra cases per 1,000 men in the screening group.
Full Story: MedPage Today (free registration) (10/29)
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Study: Rural areas rely more on H-1B physicians
Rural and high-poverty counties in the US have a higher percentage of H-1B-sponsored physicians than urban areas, according to a research letter published in the Journal of the American Medical Association. Overall, H-1B physicians made up 0.97% of the US physician workforce in fiscal 2024. An executive order signed by President Donald Trump raised H-1B visa application fees from about $3,500 to $100,000.
Full Story: MedPage Today (free registration) (10/29)
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Build Trust with Better Identity Data
Discover how a trusted identity foundation fuels personalization, powers AI, and drives enterprise-wide growth. See how leaders unify data for smarter decisions. Download the whitepaper.
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Health Policy
 
Med students may face challenges with loan caps
The new federal loan caps introduced by President Trump's tax cut law limit professional degree students to borrowing $50,000 annually, with a total cap of $200,000. This is significantly below the median cost of attending a four-year medical school, which was $318,825 for recent graduates. Critics argue that these caps could deter students from low-income backgrounds from pursuing medical careers. The cap may lead students to seek private loans with less favorable terms and push them toward higher-paying specialties in urban areas, leaving rural communities underserved.
Full Story: KFF Health News (10/27)
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The Future of Retail: What's Coming in 2026
AI personalization and seamless customer experiences defined 2025, but the retail landscape is about to shift again. Join us on November 5th for a fast-paced webinar where industry experts reveal the top trends and technologies shaping 2026. Discover how to stay ahead, boost productivity, and deliver next-level shopping experiences. Register now!
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Advancing Health Care
 
Comparing ChatGPT, Gemini, Copilot for radiology report explanations
A study in the journal Insights Into Imaging compared the ability of the large language models ChatGPT, Gemini and Copilot to interpret radiology reports for patients and found that each excelled in different ways. ChatGPT provided the most readable explanations, Gemini offered strong patient guidance and Copilot provided the most uncertain responses.
Full Story: Radiology Business (10/30)
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