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RNA molecule may regulate protein aggregation in the brain | Gene therapy shows promise in treating rare heart disease | Machine learning model predicts urine culture outcomes
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November 14, 2025
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Science Briefs
 
RNA molecule may regulate protein aggregation in the brain
The newly discovered long non-coding RNA molecule FAM151B-DT may regulate protein homeostasis in the brain. The researchers found that silencing FAM151B-DT led to increased aggregation of tau and α-synuclein, which are proteins associated with neurodegenerative diseases.
Full Story: Medical Xpress (11/12)
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Gene therapy shows promise in treating rare heart disease
A Phase 1 trial of the CRISPR-Cas9 gene therapy nexiguran ziclumeran showed an 87% reduction in serum transthyretin levels over three years for patients with transthyretin amyloid cardiomyopathy.
Full Story: MedPage Today (free registration) (11/12)
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Biomarker may predict response to breast cancer treatment
A study found that the protein FGD3 could serve as a predictive biomarker for breast cancer treatment efficacy. Researchers found a strong correlation between FGD3 levels and patient responses to chemotherapy.
Full Story: Inside Precision Medicine (11/13)
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Data Science
 
Machine learning model predicts urine culture outcomes
An XGBoost algorithm to predict urine culture outcomes demonstrated robust performance, with an AUROC of 0.834 during internal validation and 0.800 in external validation, supporting its potential application in clinical settings.
Full Story: The Journal of Applied Laboratory Medicine (11/4)
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DAPK1 could be biomarker for colorectal cancer liver metastasis
Researchers have identified death-associated protein kinase 1 as a novel biomarker for liver metastasis in colorectal cancer. The study, which used machine learning and multiomics approaches, found that DAPK1 is upregulated in metastatic tissues and associated with macrophage infiltration.
Full Story: BioMed Central (11/12)
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Tech Briefs
 
AI aids diagnosis of blood cancers
A report in the journal Science Translational Medicine details how AI can improve the diagnosis of blood cancers by automating the analysis of bone marrow smears. The researchers trained deep learning models to quickly and accurately classify cells.
Full Story: Medical Xpress (11/10)
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Transforming retail operations with mobile solutions
Retailers face labor shortages, rising customer expectations and unpredictable supply chains, which drive them to reinvent their operations. With mobile technology, retailers can provide real-time visibility, contactless payments, digital receipts and loyalty programs. This paper explores how mobile solutions transform retail operations and engage consumers.
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Policy Briefs
 
EU expands use of Hologic's Genius digital diagnostics system
Hologic's Genius digital diagnostics system has received expanded CE marking in the EU, allowing it to image and review both cell and tissue specimens. Previously approved for cell analysis, the system can now perform whole slide imaging.
Full Story: Medical Product Outsourcing (11/13)
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FDA approves once-daily pill to treat rare blood cancer
The FDA has approved Kura Oncology and Kyowa Kirin's once-daily oral treatment Komzifti for patients with acute myeloid leukemia with an NPM1 mutation, which occurs in about 30% of cases.
Full Story: Reuters (11/13)
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FDA outlines new pathway for gene editing therapies
The FDA has introduced the "plausible mechanism pathway" to accelerate the development and approval of bespoke gene editing therapies. The pathway, detailed in the New England Journal of Medicine, aims to extend the success of single-patient treatments to a broader regulatory framework.
Full Story: STAT (11/12), Fierce Biotech (11/12)
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