A review in the journal Diabetes Metabolism Research and Reviews found tirzepatide had a neutral effect on heart failure outcomes in patients with type 2 diabetes or obesity. The meta-analysis of 11 randomized controlled trials involving 13,378 participants found no significant difference in heart failure risk when compared with a placebo or other glucose-lowering drugs.

A study presented at a meeting of the Obesity Society found that more than half of patients who stop taking GLP-1 drugs regain weight within a year. The analysis of data from more than 1.2 million patients found people with type 2 diabetes were more likely to persist using the medications than those without type 2 diabetes.

Premature deaths among adults younger than 65 increased 27% from 2012 to 2022, with Black adults experiencing a higher rate than white adults, according to a study in JAMA Health Forum. The research highlights the health outcome impact of societal factors such as lack of health insurance, rising living costs and a weak social safety net, and notes that chronic diseases are a major cause of these premature deaths.

A study presented at ObesityWeek found that adolescents who reduced their body mass index by at least 10% over 26 weeks by following a reduced-calorie diet had decreased fat mass but maintained lean mass and bone mineral content. The study involved 126 adolescents with severe obesity who followed a 1,200-calorie-per-day diet for a year.

A study in JAMA Oncology that included data from more than 29,000 female nurses found that those with the greatest intake of ultra-processed foods had a higher risk of developing early onset colorectal conventional adenomas, when compared with those with the lowest consumption levels. Researchers noted that greater intake of artificially sweetened beverages was associated with a higher risk, although no specific food group was linked to the overall risk.

Telehealth and hospital-at-home programs have resumed normal operations after the government shutdown, thanks to an extension of Medicare waivers that lasts until Jan. 30. The waivers have been extended three times in less than a year.

Unapproved peptide injections are being touted by influencers and celebrities as ways to build muscle, lose weight and look younger. The peptides, often sold online or through wellness clinics, lack extensive human studies and regulatory approval, raising concerns about potential side effects, including allergic reactions and metabolic issues.

A study presented at a meeting of the Obesity Society found that tirzepatide was effective in promoting weight loss for patients with polycystic ovary syndrome, with over 90% losing at least 10% of their body weight within 10 months. The study involved 4,241 women who used a digital weight loss service.