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Endpoints News
Tuesday, 23 December 2025
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Share your perspective. Endpoints is fielding the next Biopharma Sentiment Index (BPSI), a three-minute survey that distills thousands of industry views into a quarterly benchmark. It’s one of the clearest snapshots of how people inside biopharma see the year ahead. Add your voice today.
One of my favorite ways to catch up with a friend is to ask them about the best thing they’ve eaten lately (usually after they return from a trip). Without further ado, I wanted to figure out what the best bites of the year were for health tech: 
Most overdue story: Ahead of my chat with Verily CEO Stephen Gillett at HLTH, I downloaded the company’s new Verily Me app. I’ve been covering healthcare for the past decade, and I can’t believe it’s taken me this long to download an app that can aggregate my health data from various visits into one personal health record. It feels like a necessary step as AI starts to make different forms of health data more useful.
Newest concept: Littlemen. The rise of direct-to-employer programs this year, tapping into the rising success of cash-pay rates for weight loss drugs, got us so inspired we coined a new term. The companies facilitating the direct-to-employer coverage aren’t exactly middlemen in the way PBMs are, they’re… littlemen. 
Biggest shift in fortunes: If you’d asked me a few years ago, I might’ve said UnitedHealth Group would become the first healthcare company to hit a $1 trillion market cap. Health insurers were only getting bigger. But in 2025, their businesses strained under the pressure of rising medical costs and regulatory changes — UnitedHealth especially. And now, they’re facing additional attention directly from the president
Most unexpected coverage: We covered wearables much more than expected, thanks to endorsements from the Trump administration, an FDA warning letter, and a mega funding round for smart-ring-maker Oura. I don’t expect that’ll change in 2026, with most consumer wearables companies starting to take the healthcare market more seriously.
Biggest letdown: For all the fanfare Hinge Health and Omada Health’s public offerings received, we’re still waiting on our next digital health IPO to materialize.
Most surprising trend: There’s been way more acceptance of using AI in mental healthcare, as Ngai has covered. What once was taboo has been embraced by virtual mental health companies and users alike.
The rebrand we saw on repeat: Digital health companies such as Hims and Noom are repositioning themselves as longevity companies to expand their pool of patients. I’d bet we’ll be covering more longevity plays in the year ahead.
Most heartwarming moment: Seeing so many folks join us in NYC at our happy hour last month! Thanks for being a part of it! 
- Lydia
P.S. – This is our last newsletter of 2025! We’ll be back in January, see you then! 
Here’s what’s new
White House unveils nine more ‘most favored nation’ deals as Trump says he'll target health insurers next
President Donald Trump said in the press conference that he’s planning a meeting with the top health insurers in the US, a surprise announcement that would put pressure on one of the pharma industry’s biggest foes.
Exclusive: Cellens raises $6.5M to advance physics-based test for bladder cancer
Boston-based com­pa­ny Cel­lens se­cured $6.5 mil­lion to de­vel­op its plat­form that de­tects blad­der can­cer through an ap­proach that com­bines physics and AI, End­points News learned ex­clu­sive­ly.
The Endpoints winners and losers list: Who was up and who was down in 2025
For health tech, this year's picks were: 
  • 💉Winner: Drug compounders 
  • 🏪Loser: Walgreens
Read the full list to see why. 
Quote of the week
"I’m the guy who invented scribing, and I’m gonna be the guy who destroys scribing."
Ian Shakil, chief strategy officer at Commure and founder of Augmedix, told us in October. It's our pick for Quote of the Year.
This week in health Тech
New Mountain Capital’s president of private equity and managing director Matthew Holt left the firm and is in talks to lead Thoreau, a company that would combine five of New Mountain’s health tech portfolio companies, Bloomberg reports. The deal, which Bloomberg reports might include Datavant, Swoop, Machinify, Smarter Technologies and Office Ally, is valued at $30 billion.
CMS released a request for applications providing more details about a new Medicare innovation model that tests outcomes-based payment for companies that provide care for chronic conditions with the help of technology. The model, called ACCESS (Advancing Chronic Care with Effective, Scalable Solutions), is set to kick off July 2026 and will run for 10 years. The program opens up a new market for digital health companies to tap.
Truemed, the Calley Means co-founded startup that helps people use HSA and FSA dollars to purchase things like saunas and gym equipment, raised $34 million. Andreessen Horowitz led the Series A round.
Former Amazon VP of healthcare Aaron Martin is becoming Humana’s president of Medicare Advantage. At Amazon, Martin was in charge of the company’s strategic partnerships as well as its chronic conditions and telehealth programs.
Virtual pediatric chronic care startup Clarity Pediatrics raised $14.5 million. Jackson Square Ventures led the round. The startup plans to launch virtual obesity services in 2026.
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