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2 April, 2026
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1. The tide is starting to turn in pharma's favor for the future of 340B
2. Diabetes cell therapy startup gets $79M from Canadian government
3. Trump is preparing 100% tariffs on some drugmakers, documents show
4. Novo claims that its obesity pill is better than Lilly’s. Only a head-to-head trial can prove it
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Nicole DeFeudis
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Lawsuits over the federal 340B program have been heating up for some time. In particular, I’ve been paying attention to cases that pit states and drugmakers against each other over how discounted drugs are dispensed. It’s a saga that’s been unfolding for several years, with billions of dollars on the line. In three cases, pharma appears to have a new ally: the federal government.

The DOJ has taken the position that states have “no role” in determining drugmakers' obligations. It’s an unexpected twist in litigation that's far from over. After a separate court decision this week in favor of pharma, the issue is more likely to pique the Supreme Court's interest. You can read more about it here in my latest story, and feel free to reach out with any tips on what you think the next chapter holds. 

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Nicole DeFeudis
Editor, Endpoints News
@Nicole_DeFeudis
1
by Nicole DeFeudis

Phar­ma is gain­ing ground in a years­long strug­gle over ac­cess to fed­er­al drug dis­counts.

Drug­mak­ers and the fed­er­al gov­ern­ment have his­tor­i­cal­ly been on op­pos­ing sides of con­tract phar­ma­cy pol­i­cy un­der 340B. But in a hand­ful of cas­es against state laws, they’ve be­come un­ex­pect­ed al­lies.

For the first time, the agency charged with over­see­ing the 340B pro­gram has de­cid­ed to weigh in on lit­i­ga­tion over state laws that reg­u­late how phar­ma com­pa­nies dis­pense dis­count­ed drugs.

The De­part­ment of Jus­tice, on be­half of HHS, sided with Ab­b­Vie and a lead­ing trade group when it wrote in fa­vor of tem­po­rary blocks on such laws in Col­orado, Maine and Rhode Is­land. DOJ at­tor­neys wrote in am­i­cus briefs filed in Feb­ru­ary and March that states should not have the au­thor­i­ty to en­force 340B.

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A scientist at Aspect Biosystems' labs in Vancouver (courtesy of Aspect Biosystems)
2
by Ryan Cross

An am­bi­tious Van­cou­ver start­up is try­ing to en­sure the next big di­a­betes break­through re­tains its ties to Cana­da, un­like the in­sulin de­vel­op­ers of a cen­tu­ry ago.

That start­up, As­pect Biosys­tems, has re­ceived $79 mil­lion from the Cana­di­an gov­ern­ment to pur­sue its stem cell-de­rived ther­a­py that en­ables pa­tients to pro­duce their own in­sulin.

The gov­ern­ment mon­ey comes from the Strate­gic Re­sponse Fund, which aims to help Cana­di­an in­dus­tries re­cov­er from the Trump ad­min­is­tra­tion’s tar­iffs and sup­ports re­search in ar­eas in­clud­ing bio­man­u­fac­tur­ing and ar­ti­fi­cial in­tel­li­gence.

“This gov­ern­ment deal al­lows us to have the ca­pa­bil­i­ties to go the dis­tance, which is very dif­fer­ent than 100 years ago when in­sulin left Cana­da and cre­at­ed No­vo Nordisk,” As­pect CEO and co­founder Tamer Mo­hamed told End­points News in an in­ter­view.

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US Deals Outlook 20226: What's ahead for pharma and life sciences
US biopharma still leads the world in high-risk drug development, but the road from innovation to access has never been harder to predict. Hear from top executives and investors on how they’re navigating what’s next. Join us.
President Donald Trump with Novo Nordisk CEO Maziar Mike Doustdar (center left) and Eli Lilly CEO David Ricks (center right) at the Oval Office (Andrew Caballero-Reynolds/AFP via Getty Images)
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by Anna Brown

Pres­i­dent Don­ald Trump is re­port­ed­ly set to un­veil 100% phar­ma­ceu­ti­cal tar­iffs as soon as Thurs­day, but ac­cord­ing to a draft seen by End­points News, it ap­pears they would on­ly af­fect a small por­tion of drug­mak­ers.

The draft doc­u­ment lays out how Trump is plan­ning to im­ple­ment the tar­iffs on the phar­ma in­dus­try and how drug­mak­ers with “most fa­vored na­tion” deals with the White House will be ex­empt un­til 2029.

While the White House did not im­me­di­ate­ly re­spond to ques­tions from End­points, Bloomberg News re­port­ed some de­tails of the plan Wednes­day, in­clud­ing that they could be an­nounced as soon as to­day. The draft doc­u­ment could still be sub­ject to change be­fore the ad­min­is­tra­tion of­fi­cial­ly an­nounces it.

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4
by Elizabeth Cairns

A day af­ter Eli Lil­ly gained FDA ap­proval for its obe­si­ty pill Foun­dayo, No­vo Nordisk is fight­ing back with an analy­sis that it says shows the su­pe­ri­or­i­ty of its own oral drug.

The Dan­ish drug­mak­er's claims — it says its We­govy pill pro­duces rough­ly 3% greater weight loss than Foun­dayo — pre­view what's cer­tain to be a long-run­ning com­pe­ti­tion be­tween the com­pa­nies as they make sci­en­tif­ic claims and com­pete on price.

For now, No­vo would­n't con­firm or de­ny whether it in­tends to run a head-to-head study of the two pills — the gold stan­dard for any claim of su­pe­ri­or­i­ty. What No­vo has done is crunched num­bers from the main Phase 3 tri­als of the two prod­ucts — Lil­ly's AT­TAIN-1 study of Foun­dayo and its own OA­SIS 4 tri­al of the We­govy pill.

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