News broke this afternoon that an American fighter jet was shot down over Iran. One crew member has reportedly been rescued; the other is missing. The development could change the conflict’s dynamics: if Iran were to capture the American airman alive, that could trigger another round of escalation in a war that shows no sign of easing.

And a new class of vaccines target not a single pathogen in the body, but lots of them. It is early days, with results in mice that may or may not translate to humans (or survive America’s disordered vaccine politics). But research into “everything vaccines” provides a bit of hope for readers who could use some this Easter weekend.

Finally, if you’ve been reading us all week, try our pint-sized news quiz.