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23 June, 2026
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1. Pfizer's $43B Seagen bet sours further as ADC fails in late-stage lung cancer trial
2. Sangamo’s three-decade run comes to a close as Lilly and Astellas eye assets
3.
news briefing
Boundless Bio's reverse merger; CARsgen wins first solid tumor approval for CAR-T
4. Exelixis' TKI falls short in colorectal cancer subgroup as FDA reviews approval in all-comers
5. Exclusive: Brent Saunders' latest dermatology bet gets $20M for skin longevity
6. Exclusive: RA Capital backs intranasal viral prophylactic with $34M and a plan for Phase 2b
7. Exclusive: Flagship's Abiologics uses AI to build mirror-image proteins for new drugs
8. HHS rolls out sweeping clinical trial reforms to counter China, RFK Jr. says
9. After 'redesign,' WuXi Biologics sets new timeline for Massachusetts factory completion
10. Sanofi R&D leader Houman Ashrafian to depart, Paulo Fontoura to take the reins
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Karen Weintraub
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In 2023, Pfizer spent $43 billion to buy Seagen. Now yet another drug it acquired in that purchase has failed or been sidelined. Elizabeth Cairns has the details and implications for the pharmaceutical giant’s oncology approach here.

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Karen Weintraub
Deputy Editor, Endpoints News
Albert Bourla, Pfizer CEO (AP Photo/Markus Schreiber)
1
by Elizabeth Cairns

The fail­ure of a Pfiz­er an­ti­body-drug con­ju­gate in its im­por­tant late-stage lung can­cer test is ex­act­ly what the New York drug­mak­er didn’t need.

The as­set...

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2
by Lei Lei Wu

De­spite be­ing an ear­ly play­er in the gene edit­ing field and de­vel­op­ing nu­mer­ous clin­i­cal pro­grams, Sang­amo Ther­a­peu­tics will be sell­ing off its partswith­out ma­te­ri­al­iz­ing...

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News Briefing: Quick hits from the biopharma web
3
by ENDPOINTS

Plus news about Defini­um Ther­a­peu­tics, uniQure, Moon­Lake Im­munother­a­peu­tics, Ver­sant Ven­tures, Corx­el Phar­ma­ceu­ti­cals and US WorldMeds.

🇨🇳 BOLD gives up: Bound­less Bio BOLD, which faced clin­i­cal...

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4
by Ayisha Sharma

De­spite the suc­cess of Ex­elix­is’ oral ty­ro­sine ki­nase in­hibitor in a broad­er pop­u­la­tion, the can­di­date failed to sig­nif­i­cant­ly im­prove sur­vival in col­orec­tal can­cer pa­tients with­out...

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The Endpoints 100: Despite all the turmoil, biotech is having a moment
A year ago, biotech was in its bleakest stretch in a decade. Now IPOs are rebounding and China deals are heating up. John Carroll and a panel of industry leaders dig into the latest Endpoints 100 results and uncover what’s next for the sector.
Brent Saunders, co-founder of Rapalogix Health (Credit: Bausch + Lomb)