As­traZeneca’s shares dropped in ear­ly trad­ing Thurs­day af­ter a heart dis­ease treat­ment it is de­vel­op­ing with Io­n­is Phar­ma­ceu­ti­cals un­ex­pect­ed­ly failed in a late-stage tri­al. The UK com­pa­ny had aimed to show that its an­ti­sense drug Wain­ua could pre­vent car­dio­vas­cu­lar death or events like heart at­tack and stroke in pa­tients with a con­di­tion called transthyretin-me­di­at­ed amy­loid car­diomy­opa­thy (AT­TR-CM)...