And, cancer detection is delayed in men.

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Health Rounds

Health Rounds

By Nancy Lapid, Health Science Editor

Hello Health Rounds readers! Today we highlight a study that may bring fresh hope to some lung cancer patients believed to have terminal disease. We also report on a troubling men's health trend, and on a discovery that could upend human biology assumptions based on rodent research.

We are proud to announce Health Rounds was named the Best Science Newsletter at the Publisher Awards in London last night. A big thank you to our community, we hope you continue to enjoy this newsletter.

Among our breaking news stories: Overcrowding and a lack of clean water among biggest health risks from Venezuela quakes says PAHO, China adds second GLP-1 diabetes drug to essential medicine list; South African regulators issue recall of Ozempic copies; and India's Dr Reddy's sees semaglutide supply disruption lasting until at least late October.

Also: Trump CDC nominee Schwartz set for US Senate confirmation hearing; UnitedHealth says most home-health diagnoses were supported in 2025; Bayer seeks to end federal Roundup litigation after Supreme Court win; and Congo Ebola response workers protest that they have not been properly paid.

 

Industry Updates

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  • Novo Nordisk launches weekly insulin shot Awiqli in India
  • Sino Biopharmaceutical, GSK expand alliance with China rights to respiratory drugs
  • AstraZeneca, Daiichi near UK pricing deal for breast cancer drug
  • New York sues 3M, DuPont, others over 'forever chemicals' in consumer goods
  • AstraZeneca's Wainua fails key heart disease trial and shares tumble
 
 

Obamacare insurers ask for second-highest premiums increase since 2018

Signs for former Obamacare health insurance plans lay next to a fence in Columbia, South Carolina. REUTERS/Shannon Stapleton/File Photo

Companies offering Obamacare health insurance plans next year are requesting payment rates representing a 14% median increase to premiums over 2026 rates, according to data from health policy research group KFF.

The proposed ‌rate for 2027 represents the second-highest increase since 2018, KFF said. 

 

Study Rounds

Lung transplants may save some terminal cancer patients

 

The long-held guidance that patients with stage IV lung cancer should not be eligible for lung transplants is being challenged by findings from a new study, at least for a subset of patients.

Tracking adults with terminal lung cancer confined to the lungs who were out of treatment options, doctors found lung transplantation was associated with substantially better early survival than medical management alone.

Seventeen such patients underwent lung transplant and 81 received medical management alone, in a study reported in JAMA.

A year later, every transplanted patient was still alive, compared with fewer than half of the similar cancer patients treated with medical therapies.

While stage IV lung cancer has usually spread beyond the lungs, patients in this study belonged to a subset whose cancer remains confined to both lungs even as it progresses to respiratory failure, the researchers noted.

Their immediate cause of death is often not widespread systemic cancer, but progressive failure of cancer-filled lungs.

“This work changes what we can imagine for a highly selected group of patients who were previously considered beyond the reach of curative-intent intervention,” study leader Dr. Ankit Bharat of Northwestern Medicine in Chicago said in a statement.

The 100% one-year survival rate among the cancer patients was also higher than the 88% rate among patients who received lung transplants for traditional reasons, suggesting that giving lungs to certain advanced cancer patients is not a waste of donated organs that are in short supply. 

“When the cancer is rigorously proven to be confined to the lungs, when standard therapies have been exhausted, and when the lungs themselves have become the life-limiting organ, transplantation may offer a new path forward,” Bharat said.

 

Read more about lung cancer on Reuters.com

  • Pfizer's experimental drug misses main goal of lung cancer trial
  • Jazz Pharmaceuticals lung cancer drug fails main trial goal
  • Akeso lung cancer drug helps patients live 15% longer than immunotherapy in China trial
  • Kelun, Merck's lung cancer combo improves survival in late-stage China trial
 

Cancer is found later more often in men 

Cancer is found at late stages more often in men than in women, according to a U.S. study that may provide insight into gender discrepancies in cancer outcomes since the more advanced the disease at diagnosis, the worse the prognosis tends to be.

Reviewing more than 2.4 million cases diagnosed from 2015 to 2022, researchers identified 16 cancers in which men were significantly more likely than women to be diagnosed after the disease had spread to local lymph nodes.

Such regional-stage diagnoses were 151% more likely in men than in women with tongue cancer, 93% more likely with salivary gland cancer, 80% more likely with oropharyngeal cancer, 74% more likely with thyroid cancer, and 67% more likely with stomach cancer, researchers noted in a report in Cancer Epidemiology, Biomarkers & Prevention.

Late-stage cancers that have spread to other organs were also more common than localized tumors in men versus women for 17 cancer sites, with the largest differences seen in melanoma and cancers of the tongue, thyroid, salivary gland, and stomach.

For a small number of cancer sites – including the larynx and the bladder – men were less likely than women to be diagnosed at later stages.

These patterns persisted across different races, ethnicities and neighborhood income levels.

One explanation could be differences in cancer screening rates, study leader Beth Maclin of the U.S. National Cancer Institute said in a statement.

And women see doctors more often than men, which could mean more opportunities for clinicians to catch cancer symptoms earlier, she noted. Clinicians may also perceive cancer symptoms differently in males and females, leading to different types of diagnostic tests, she added.