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6 October, 2026
$142 billion in 340B medicine markups
Nearly 60% of 340B spending is driven by medicine markups. The federal 340B program is now a $244B behemoth yet there is little oversight or accountability, unlike most federal programs. Learn more.
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The Patent Clock Is Al­ready Run­ning. Why De­vel­op­ment Speed Is Al­so a Com­mer­cial Strat­e­gy
spotlight
top stories
1. ArriVent's lung cancer drug fails key late-stage trial, stock tanks
2. AstraZeneca heralds new R&D facility in that ‘other’ Cambridge
3. Forbion gets Lilly's backing in Dutch VC's largest-ever fundraising haul
4.
news briefing
KymaThera, Rouge raise VC funding; Vaxcyte, Spyre do public offerings
5. Lycia seeks IPO for antibody degraders as TRexBio, Retension set terms
6. AbbVie, Genmab trot out first-line DLBCL win for Epkinly in challenge to Polivy
7. Exclusive: Genentech parts ways with a key AI leader in latest high-profile exit
more stories
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Karen Weintraub
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ArriVent BioPharma was early to license a drug from China, in its case, the EGFR-inhibitor firmonertinib for advanced lung cancer. As Lei Lei Wu explains, that trial has now failed in Phase 3, leaving patients with EGFR exon 20 insertion-mutant NSCLC with one less potential option.

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Karen Weintraub
Deputy Editor, Endpoints News
1
by Lei Lei Wu

Ar­riVent Bio­Phar­ma, an ear­ly adopter of the Chi­na li­cens­ing mod­el, re­port­ed that its lead lung can­cer drug failed a Phase 3 tri­al.

Fir­mon­er­tinib, an EGFR...

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From left: AstraZeneca SVPs Sharon Barr and Susan Galbraith, Massachusetts Gov. Maura Healey, and CEO Pascal Soriot. (Karen Weintraub/Endpoints News)
2
by Karen Weintraub

As­traZeneca prides it­self on in­vest­ing rough­ly a quar­ter of its an­nu­al rev­enue in­to re­search and de­vel­op­ment. On Mon­day, the com­pa­ny in­au­gu­rat­ed a 570,000-square-foot build­ing in...

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3
by Kyle LaHucik

Dutch life sci­ences in­vestor For­bion has col­lect­ed its largest amount of cap­i­tal to date, pulling in €2.3 bil­lion ($2.6 bil­lion) across two funds.

For­bion will...

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News Briefing: Quick hits from the biopharma web
4
by Kyle LaHucik

Ky­maThera gets $80M: The San Diego biotech raised the Se­ries Bto de­vel­op its pan-mu­tant se­lec­tive PI3Kα in­hibitor called K-1728. The ex­per­i­men­tal oral med­i­cine is...

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5
by Kyle LaHucik

Ly­cia Ther­a­peu­tics, a pro­tein degra­da­tion start­up built around sci­ence out of the lab of No­bel lau­re­ate Car­olyn Bertozzi, has filed for an ini­tial pub­lic of­fer­ing...

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